Home Health-Fitness Advil as Acne Treatment Pimples can appear out of nowhere, leaving your face appearing red and irritated. Zap away problem acne with an Advil Liqui-Gel. This pimple-fighting formula has been used by makeup artists backstage during fashion shows and on the set of photo-shoots. Simply open up an Advil gel cap and apply the liquid directly to the pimple to immediately decrease swelling.